Lifestyle Africa is a diet and physical activity program adapted from the US National Diabetes Prevention Program to make it more suitable for low- and middle-income country contexts. It is designed for delivery by community health workers or lay facilitators and utilizes video-guided sessions. Video sessions are used to deliver content that would normally need to be delivered by a health professional with expertise in lifestyle modification. Program sessions have also been simplified to decrease the level of health literacy and numeracy needed to participate in the program. The program includes a training curriculum and training materials for training lay facilitators to deliver the program. Other than a mini or regular projector the equipment required is basic (e.g., paper, pens, markers). The version currently available was developed for delivery in a Xhosa-speaking urban community in South Africa. The program reflects the target community’s culture, food, and lifestyle in South Africa. Although video sessions and materials were developed in Xhosa all materials and session video scripts are also available in English. More details of the program are provided here.